Solid dispersion comprising N4 - (4 - (1,2,4 triazolo 1,5-a pyridine - 7 - iloxi) - 3-methylphenyl) - N6 - (4,4 - dimethyl - 2 - 4.5 - dihidrooxazol il) quinazoline - 4.6 - diamine and a Polymer dispersion; Preparation Process; Pharmaceutical composition use in the treatment of breast cancer, gastric, colorectal, Pancreatic, among others.

摘要

A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.