Piridona heteroaryl compounds and substituted AZA piridona, BTK Kinase Inhibitors; Pharmaceutical composition that comprises; Process for preparing the pharmaceutical composition, Pharmaceutical Kit; and use for the treatment of inflammation, cancer, immune disorders, Disorders n Eurologicos, among others.

摘要

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X 1 , X 2 , and X 3 are N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.