method of predicting the effectiveness of treatment of patients with non hodgkin's lymphoma of high degree u0437u043bu043eu043au0430u0447u0435u0441u0442u0432u0435u043du043du043eu0441u0442u0438

摘要

the invention belongs to the field of medicine, more specifically to medical genetics, oncology and u043eu043du043au043eu0433u0435u043cu0430u0442u043eu043bu043eu0433u0438u0438.the essence of the proposed method is that researching the polymorphism G13494A 6 u0438u043du0442u0440u043eu043du0430 gene u0442u044053 patient and in identifying the patient u0433u043eu043cu043eu0437u0438u0433u043eu0442u043du043eu0433u043e genotyping g / g in d u0430u043du043du043eu043c u043bu043eu043au0443u0441u0435 predict low treatment effectiveness (a small probability of 5 years survival of the patient and the absence of recurrence).and in identifying the patient u0433u0435u0442u0435u0440u043eu0437u0438u0433u043eu0442u043du043eu0433u043e genotyping and / or g / a in the u043bu043eu043au0443u0441u0435 predicting the effectiveness of treatment (high probability of u0440u0435u043cu0438u0441u0441 ai and the five year survival of a patient).the proposed method is robust against different choices u0430u0444u0435u0441u0441u0438u0432u043du044bu0445 u043du0445u0437u043b, technically simple, gives the possibility to obtain a more complete picture of the effectiveness of prediction efficiency of treatment (the probability of achieving remission, surviving for 5 years from the date of diagnosis and the probability of survival for this period without a relapse).