ETHANRECEPT DRUGS STABILIZED BY MEGLUMIN

摘要

The present invention is an aqueous stabilized preparation of etanercept, containing etanercept and stabilizing ingredients to slow the development of instability, prevent aggregation and / or fragmentation of etanercept in a preparation, these stabilizing ingredients include at least one of the following: or (b) meglumine in combination with sucrose; or (c) meglumine in combination with sodium chloride; or (d) meglumine in combination with sodium chloride and sucrose. Definitions of various technical terms used in the following discussion are given below in the “Definitions” section and in the rest of the text of the description of the invention. The stabilized preparations of etanercept according to the invention cause an increase in stability during long-term storage.