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Modified urinary plasminogen activator (u-p a) polypeptides with altered substrate specificity or activity and compositions and uses thereof
Modified urinary plasminogen activator (u-p a) polypeptides with altered substrate specificity or activity and compositions and uses thereof
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机译:具有改变的底物特异性或活性的修饰的尿纤溶酶原激活剂(u-p a)多肽及其组成和用途
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摘要
Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macro globulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases
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