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A PHARMACEUTICAL COMPOSITION OF NIOSOMAL GEL FOR THE TOPICAL DELIVERY OF LORNOXICAM
A PHARMACEUTICAL COMPOSITION OF NIOSOMAL GEL FOR THE TOPICAL DELIVERY OF LORNOXICAM
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机译:洛诺昔康局部递送的脂质体的药物组合物
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摘要
Niosomes are spherical submicroscopic structures and are prepared by using nonionic surfactants such as Tweens, Spans etc. Non-ionic surfactant based vesicles (niosomes) are formed from the self-assembly of non-ionic amphiphiles in aqueous media resulting in closed bilayers structures. The closed bilayers structure is an assembly in which the hydrophobic parts of the molecule are protected from the aqueous solvent and the hydrophilic head groups are in contact with aqueous environment. They have a capability to encapsulate lipophilic and hydrophilic drug molecules. This system can be employed for topical drug delivery. The niosome is deposited into the stratum corneum due to vesicle in nature. After that they start releasing drug, and it is helpful for local action instead of systemic action. Thus the present invention deals with the preparation of topical niosomal based gel formulation of Lornoxicam. The work includes preparation of niosomes by thin film hydration with sonication was used an optimization of various process parameters and excipients. The Niosomes were then evaluated for various physicochemical characteristics. The prepared niosomes are then incorporated into topical gel dosage forms.
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