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SOLID LIPID NANOPARTICLES BASED FORMULATION OF ANTIFUNGAL AGENT AND PREPARATION METHOD THEREOF.
SOLID LIPID NANOPARTICLES BASED FORMULATION OF ANTIFUNGAL AGENT AND PREPARATION METHOD THEREOF.
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机译:基于固体脂质纳米颗粒的抗真菌剂配方及其制备方法。
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摘要
Solid lipid nanoparticles are the spherical lipid particles in the size in the range of 5-1000 nm. It consists of a lipid core matrix in which the drug in encapsulated. The lipid phase is stabilized by using surfactants. Solid lipid nanoparticles combine the advantages of the other colloidal delivery systems like Microemulsions, nanoemulsions, liposomes, niososmes and polymeric nanoparticles and are introduced as an alternative to these delivery systems. The present invention provides compositions comprising solid lipid nanoparticles based gel of terbinafine hydrochloride. The said gel formulation comprising of at least one lipid component, at least one surfactant and at least one cosurfactant. The nanoparticles dispersion is incorporated into a gel to form a stable formulation. The solid lipid nanoparticles are prepared by melt emulsification method using high pressure homogenization technique. The nanoparticles may have a mean diameter, measured by photon correlation spectroscopy in the range of from about 50 nm to about 1000 nm. In the present embodiment, the pharmaceutical composition of terbinafine have enhanced skin deposition and improved antifungal activity.
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