A NOVEL PLANT DERIVED ALKALOID OF QUINOLONE CLASS WITH CYTOTOXIC ACTIVITY

摘要

The present invention relates to a novel cytotoxic quinolone of structural formula 5,7-dimethoxy-3-phenyl-l-ethyl-l,4-dihydro-4-quinolone isolated from the stem bark of Crataeva nurvala and a method of isolation thereof. The cytotoxic quinolone possesses an N-ethyl functionality which shows anti-proliferative and apoptosis inducing properties against a number of cancerous cells most preferably against cervical cancer and prostrate cancer cells.