INDUCED MALIGNANT STEM CELLS OR PRE INDUCTION CANCER STEM CELLS CAPABLE OF SELF REPLICATION OUTSIDE OF AN ORGANISM PRODUCTION METHOD FOR SAME AND PRACTICAL APPLICATION FOR SAME

摘要

Disclosed are inducible cancer stem cells which are capable of in vitro self replication and which are useful in research into cancer treatment and cancer related drug development. Also disclosed are a production method for the above cells cancer cells induced from the above stem cells and a practical application of the cells. The disclosed inducible cancer stem cells which are capable of in vitro self replication are characterised by satisfying requirements (1) and (2): (1) expressing six genes (POU5F1 gene NANOG gene SOX2 gene ZFP42 gene LIN28 gene and TERT gene) selected from among a specified gene group; (2) (a) having an abnormality which is either the modification of an endogenous cancer suppression gene or the up regulation of an endogenous cancer related gene.