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AN IMPROVED PROCESS FOR THE PREPARATION OF BETA-KETO ESTERS OF FORMULA I.
AN IMPROVED PROCESS FOR THE PREPARATION OF BETA-KETO ESTERS OF FORMULA I.
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机译:制备式I的β-酮酮酯的改进方法。
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摘要
The instant invention relates to an improved batch process for the preparation of formula I by cross Claisen condensation using lithium metal amine chemically represented as LiNH2 of formula II as lithium source over conventionally used n-butyl lithium, lithium diisopropylamide referred as LDA, lithium hexamethyldisilazane referred as LiHMDS. wherein R is straight or branched chain alkyl group, Represents any of hydrogen, an alkyl group of 1 to 12 branched or straight chain carbon atoms which may have a substituent, an alkenyl group of 2 to 12 carbon atoms which may have substituent, an aryl group of 6 to 12 carbon atoms which may have a substituent, an aralkyl group of 7 to 12 carbon atoms which may have a substituent, a cyano group, methylcyano group, a carboxyl group and alkoxycarbonyl group, hydroxy group, R2 is a hydroxy group or keto group, R3 is independently hydrogen, straight or branched chain alkyl group,
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