SYNERGISTIC EFFECT OF PIPERINE WITH DIPHENOXYLATE IN TREATING DIARRHOEA.

摘要

Despite the availability of several remedies to treat diarrhoea including botanicals and chemical agents, yet there is a great need for the evaluation of agent to meet the challenges of upcoming era regarding disease burden. Hence, there is a need of a drug which will treat the diarrhoea effectively with minimum side effects. Diphenoxylate is an effective antidiarrhoeal agent. But it produces undesirable effect of like nausea, drowsiness, diziness, restlessness and abdominal cramps. Higher doses have CNS effects & prolonged use can potentially lead to opioid dependence. The present invention provides synergistic effect of Piperine with Diphenoxylate causing potentiation of antidiarrhoeal activity of Diphenoxylate by Piperine. Particularly, the present invention provides decrease in effective antidiarrhoeal dose of the Diphenoxylate when given with Piperine could result in reducing the dose dependent side effect of Diphenoxylate which make the Diphenoxylate suitable for treatment of acute as well as chronic diarrhoea.