ULTRAVIOLET SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF ACID DISSOCIATION CONSTANT

摘要

An analytical method for determination of Acid dissociation constant (pKa) and partition coefficient (logP) of Tramadol Hydrochloride by using Ultraviolet spectrophotometer. Method is developed, optimized and validated by using inexpensive solvents and simultaneous equation method. The present invention provides a Ultraviolet spectrophotometric method or process for determining pKa / log P value of Tramadol Hydrochloride. The present invention provides a simple, accurate, precise, easy and specific method using Ultraviolet spectrophotometer for determining pKa / log P value. The method described in this research work for the determination of pKa and LogP of tramadol hydrochloride is simple, accurate, sensitive, reproducible and economical. The proposed method utilizes inexpensive solvents. The method could be applied for routine analysis in quality control laboratories.