A PROCESS FOR THE PREPARATION OF THIOSEMICARBAZONES ENCAPSULATED METAL NANOPARTICLES AS POTENT ANTI-TUBERCULOSIS AGENTS

摘要

Thiosemicarbazone derivatives were synthesized by reacting thiosemicarbazide with substituted aldehydes and ketones using green solvent (PEG 400) in acidic catalyst. Metal naono-particle (silver, nickel, cobalt, iron, manganese, copper, vanadium, chromium, cadmium, molybdenum") encapsulated thiosemicarbazone derivatives were obtained by reduction method. Anti-tuberculosis activity against Mycobacterim tuberculosis of metal nano-particles encapsulated thiosemicarbazone derivatives has been tested and compared against standard Rifampicin. Cytotoxicity by hemolysis method of obtained product is less as compared with standard anti-TB Rifampicin drug.