Recruitment activity of bifunctional molecules with Antibodies and initial Inhibitory activity against human immunodeficiency virus

摘要

Referring to a Heterocyclic Compound of formula (a), which is an extreme ABT binding Antibody that includes a hapten; Linker is a Molecule which binds Chemically linking the ABT ry or directly to the indole Group in which the carbon Atom is bound to the ry is an aryl Group; Or heteroaromatico ry is romantic; or, NHC (o) NH, S (OR) 2o, among others; x2 is H (CH2) Noh (CH2) ncooh,Among others, X3 is H (CH2) Noh (CH2) ncooh, among others; r1 is H, or C1 - C3 alkyl; R is 0 OR 1; K is 0, 1, 2 or 3; n is an integer of 0 OR 1 to 6; Y3 is H or alkyl C1 - C3 RN is H, or C1 - C3 optionally substituted alkyl or Halogen. It also relates to a Pharmaceutical composition. These compounds are inhibitors of HIV