首页> 外国专利> Combining panobinostat with ruxotinib to treat cancer is like a kind of diffuse tumor

Combining panobinostat with ruxotinib to treat cancer is like a kind of diffuse tumor

机译:Panobinostat和ruxotinib联合治疗癌症就像一种弥漫性肿瘤

摘要

It refers to a drug synthesis, including: (a) a JAK inhibitor, which is (R) - 3 - (4 - (7h pirrolo [2, 3-d] pirimidin-4-il) - 1h-pirazol-1-il) - 3-cyclopentanediol (ruxotinib), 10-20 mg / day; (b) A n-octyl-3 - [2 - (2 - (2-methyl-1-indoli-3-yi) - ethyl] - amino methyl] phenyl-2e-2-phenyl (panobnostat) taken every two weeks in 10 to 30 mg, three times a week; in this case, the compound contained is a separate or single formulation. This combination is useful in the treatment of chronic leukemia, veradomia, and basic thromboses,Primary fibrosis, chronic neutrophilic leukemia
机译:它指药物合成,包括:(a)JAK抑制剂,为(R)-3-(4-(7h吡咯罗[2,3-d] pirimidin-4-il)-1h-吡唑-1- il)-3-环戊二醇(ruxotinib),10-20 mg /日; (b)每两周服用一次n-辛基-3-[2-(2--(2-甲基-1-吲哚-3-乙)-乙基]-氨基甲基]苯基-2e-2-苯基剂量为10到30毫克,每周3次;在这种情况下,所含化合物为单独或单一制剂,这种组合可用于治疗慢性白血病,Veradomia和基本血栓形成,原发性纤维化,慢性中性粒细胞白血病

著录项

  • 公开/公告号PE20140604A1

    专利类型

  • 公开/公告日2014-05-13

    原文格式PDF

  • 申请/专利权人 NOVARTIS AG;

    申请/专利号PE20160201300

  • 申请日2012-06-13

  • 分类号A61K31/4045;A61K31/519;

  • 国家 PE

  • 入库时间 2022-08-21 15:56:43

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