2. Vaccine development procedure containing at least two antigens that can be adsorbed in alumina

摘要

It refers to a dissolved vaccine composition, including: (a) alumina (AlOOH);(b) a surface antigen of hepatitis B;(c) Haemophilus influenzae type B (Hib) antigen, which is composed of polyurethane (PRP-T) encapsulated in proteome;(d) antigens for diphtheria, tetanus, poliomyelitis and pertussis. It also refers to a vaccine preparation procedure, which includes (1) adsorption of HBsAg on AlOOH to obtain an AlOOH / HBsAg complex, (II) mixing AlOOH / hbcsag compound with Hib antigen, containing 100 mg / ml cation and phosphate concentration, 35-45 mmol / L