Hydroxyalkylstarch and polypeptide conjugate, process for the preparation of that conjugate, the use thereof and the pharmaceutical composition containing the hydroxyalkylstarch and polypeptide conjugate

摘要

The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS moecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).