首页>
外国专利>
NOVEL INDOLE DERIVATIVE HAVING CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP
NOVEL INDOLE DERIVATIVE HAVING CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP
展开▼
机译:带有氨基甲酸酯基,脲醛基和取代的氧基的新型吲哚衍生物
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to synthetic studies on novel indole derivatives having a carbamoyl group, a ureido group and a substituted oxy group or a salt thereof, and pharmaceutical actions of the derivatives. The compound and a salt thereof represented by the general formula (1) has an IRK² inhibitory activity and is useful as a preventive and/or therapeutic agent for diseases considered to be associated with IKK². In the formula, R 1 represents a hydrogen atom, a lower alkyl group which may have a substituent, a hydroxy group, or a lower alkoxy group which may have a substituent, or the like; R 2 represents a hydrogen atom, a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, or a heterocyclic group which may have a substituent, or the like; R 3 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group which may have a substituent, a lower alkynyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, or the like; m represents 0, 1, 2, or the like.
展开▼
机译:本发明涉及对具有氨基甲酰基,脲基和取代的氧基的新型吲哚衍生物或其盐的合成研究,以及该衍生物的药理作用。通式(1)表示的化合物及其盐具有IRK 2抑制活性,可用作被认为与IKK 2有关的疾病的预防和/或治疗剂。式中,R 1表示氢原子,可以具有取代基的低级烷基,羟基或可以具有取代基的低级烷氧基等。 R 2表示氢原子,可以具有取代基的低级烷基,可以具有取代基的低级环烷基,可以具有取代基的芳基或可以具有取代基的杂环基等。 R 3表示卤原子,可以具有取代基的低级烷基,可以具有取代基的低级烯基,可以具有取代基的低级炔基,可以具有取代基的低级环烷基,芳基可以具有取代基,可以具有取代基的杂环基等。 m表示0、1、2等。
展开▼