PROCESS FOR OBTAINING PEPTIDES WITH ANTI-HYPERTENSIVE EFFECT FROM MEDUSA

摘要

PROBLEMS TO BE SOLVED 1. PROCEDURES FOR OBTAINING PEPTIDES FROM MEDUSA USE THE WHOLE ANIMAL, WHICH TAKE TO THE INCORPORATION OF NEMATOCYTE TOXINS AND CAN CAUSE TOXIC EFFECTS IN HUMANS, AS A HEMOLITHIC EFFECT, IF THEY DO NOT PROCEED TO THEIR RIGOROUS SEPARATION. 2. THE INTENSITY OF THE ANTI-HYPERTENSIVE EFFECT OF THE PEPTIDES PREVIOUSLY OBTAINED FROM MEDUSA IS NOT PROPERLY COMPARED TO THOSE OF LARGELY USED DRUGS LIKE, FOR EXAMPLE, CAPTOPRIL. SOLUTION 1. A PROCESS FOR OBTAINING PEPTIDES FROM MEDUSAES THAT IS FREE OF TOXINS, WHERE THE HYDROLYSIS IS CARRIED OUT AFTER THE PRE-TREATMENT WITH REMOVAL OF THE PARTS CONTAINING NEMATOCISTS. 2. A process for obtaining peptides whose antihypertensive effect has been compared with that of the captopril drug is disclosed, and the drug is found to be approximately 10 times more potent than the peptides of the medusa. HOWEVER, THE DRUG PRESENTS THE SIDE EFFECTS OF THE SULFIDRILO GROUP, WHICH THE MEDUSA PEPTIDES DO NOT OWN.