Composition of triterpenoides acids obtained from the extract of thymus mastichina and their medicinal uses

摘要

The study guided by the cytotoxicity of dichloromethane and ethanol extracts of thymus mastichina L.Using the line cell cancer of the cu00d3lon HCT has allowed the identification of nine compounds, sacuranetina (1), (2), esterubina acid oleanu00d3lico (3), ursu00d3lico acid (4), lutein (5), B - sitosterol (6), (7) rosmaru00cdnico acid, 6 - hidroxiluteolin - 7 - - B - glucopiranu00d3sido (8) and 6 hidroxiapi Genin - 7 - O - B - glucopiranu00d3sido (9).These were tested for their cytotoxicity against cancer cells of the line cu00d3lon HCT. The compound 4 showed cytotoxicity with a value gi50 6.8 microg / ml. a frau00c7u00c3o composed of a mixture (1: 1) of acids triterpenoides 3 and 4 exhibited enhanced cytotoxicity with a gi50 2.8 u039cicrog / ml, suggesting a sinergu00c9tico behavior.The presence of these constituents identified by activity guided by cytotoxicity against cancer of the cu00d3lon indicates that extracts of t. mastichina L. may have in medicine, in the treatment of tumour diseases and / or cancer.