GAMMA LACTONE OXABICYCLO 3.3.0 OCTANE POLYFUNCTIONAL CYCLOPENTANIC CHLROESTER KEY COMPOUNDS PREPARED BY STEREOSELECTIVE TRANSFORMATION OF amp;Dgr; - LACTONE INTERMEDIATES AND PROCESSES FOR PREPARING THE SAME

摘要

The invention relates to a process for preparing γ - lactone compounds used as intermediates in the syntheses of therapeutic compounds. According to the invention, the process consists of the acid alcoholysis of δ - lactone alcohols into chloroester compounds, deprotection of the secondary alcohol group with an ether group or silyl ether group in the protected chloroester compounds, primary alcohol groups as aryl-esters or alkyl-ester and the basic hydrolysis of ester groups and the closure of γ - lactone ring, there resulting Corey γ - lactone compounds, either selectively substituted or unsubstituted.