PROCESS OF OBTAINING MULTIFUNCTIONAL MICRO AND NANOCOMPOSITE SPHERES WITH SILVER NANOPARTICLES COATED WITH BIODEGRADABLE POLYMERS

摘要

Invention herewith described refers to the simple way for synthesis of micro and nanocomposite spheres of biodegradable polymer with finely dispersed silver nanoparticles in a polymer matrix in order to implement in the field of the controlled delivery of drugs and, primarily, to overcome the resistance to antibiotics. The silver nanoparticles are obtained by a modified chemical reduction method using sucrose or glucose as reducing agents and the poly(α, γ L glutamic acid) as a stabilizer. The silver nanoparticles are incorporated into the polyester PLGA by the physicochemical solvent/non-solvent method. Into the solution of poly (lactide-co-glycolide) in acetone there is added to the aqueous solution with silver nanoparticles and then the alcohol precipitation is done with methanol or ethanol. After the precipitation, the particles are stabilized with zeta potential, which created a PVA or PVP and then they are centrifuged, decanted and dried.