Normal;heading 1;heading 2;heading 3;COMPOSITION OF PD-1 ANTAGONIST AND A POTENTIATING AGENT FOR SIMULATING A T CELL RESPONSE

摘要

Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.