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METHOD FOR TREATING NEWBORNS WITH PNEUMONIA IN HERPESVIRUS INFECTION

机译：疱疹病毒感染肺炎新生儿治疗方法

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摘要

A method for treating the newborns with pneumonia in herpesvirus infection comprises the basic therapy. Furthermore, in the cases of hyperimmune response (thymomegalia, increased T helper/T suppressor ratio, increased phagocytosis, increased level of proinflammatory cytokines), Actovegin and Flavozid are prescribed. In the cases of hypoimmune response (thymus hypoplasia, decreased T helper/T suppressor ratio, increased phagocytosis, decreased IgG and IgA, decreased IL-6 and IL-8), Bioven and freshly frozen plasma are provided at the age-related doses.

机译：一种治疗疱疹病毒感染的肺炎新生儿的方法包括基本疗法。此外，在高免疫反应（胸腺增生，T辅助/ T抑制比增加，吞噬作用增加，促炎细胞因子水平增加）的情况下，应使用Actovegin和Flavozid。在免疫应答低下的情况下（胸腺发育不全，T辅助/ T抑制物比率降低，吞噬作用增加，IgG和IgA降低，IL-6和IL-8降低），以年龄相关剂量提供Bioven和新鲜冷冻血浆。

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公开/公告号UA85807U

专利类型
公开/公告日2013-11-25

原文格式PDF
申请/专利权人 KOLOMIICHENKO TETIANA VASYLIVNA;
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申请/专利号UAU201308914U
发明设计人 KOLOMIICHENKO TETIANA VASYLIVNA;ZHDANOVYCH OLEKSII IHOROVYCH;ZNAMENSKA TETIANA KOSTIANTYNIVNA;KOKHANOV IHOR VADYMOVYCH;ZHYRAVEL IRYNA ANATOLIIVNA;
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申请日2013-07-16
分类号A61K31;
国家 UA
入库时间 2022-08-21 15:56:12

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1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期

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