Effective human leukemia labeling using designed anti-cd123 chemoreceptor cells

摘要

The Invention provides compositions and Methods for the treatment of Leukemia, for example, acute myeloid leukemia (AML) and acute Lymphoid Leukemia B Cells (B - all). The Invention also relates to at least a Chimeric Antigen receptor (CAR) specific to CD123, vectors comprising the same, and T cells that comprise the recombinant car CD123.The Invention also includes Methods of Administration of a T cell that expresses a GM car comprising a binding domain CD123. The Invention also includes Methods of bone marrow Ablation for use in treatments that require reconditioning or bone marrow transplantation.