NOVEL ANTIFUNGAL 5,6-DIHYDRO-4iH/i-PYRROLO1,2-ia/i1,4BENZO- DIAZEPINES AND 6iH/i-PYRROLO1,2-ia/i1,4BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES(54) Title (FR): NOUVELLES 5,6-DIHYDRO-4H-PYRROLO1,2-iA/i1,4BENZODIAZÉPINES ET 6H-PYRROLO1,2-iA/i1,4BENZODIAZÉPINES SUBSTITUÉES PAR DES DÉRIVÉS HÉTÉROCYCLIQUES ANTIFONGIQUES

摘要

The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo- [1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I) wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.