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nanoparticles of silica, drugged with a variety of dyes, characterized by transfer of energy with high efficiency and capable of stokes shift adjustable
nanoparticles of silica, drugged with a variety of dyes, characterized by transfer of energy with high efficiency and capable of stokes shift adjustable
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机译:含有多种染料的二氧化硅纳米颗粒,其特征在于高效的能量传递,并且能够进行行程调整
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摘要
The present invention relates to silica nanoparticles comprising at least two dyes. Said dyes have a respective relationship of donor-acceptor couple in an energy transfer process and have a molar absorption coefficient ≧10,000 M−1 cm−1 for the considered spectral region, a fluorescence quantum yield ≧0.01, good overlap integral, according to the Förster theory, between said donor and said acceptor dye; said active compounds may be lipophilic or may present a functionality useful for the introduction of a trialkoxysilane moiety. The dyes provide an efficient energy transfer process. Said nanoparticles are useful as probes in the field of medicine, in particular therapy and diagnostics, more particularly in theranostics, and in the field of analytical chemistry.
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