Compounds of N- (1-phenyl-2-arylethyl) -4,5-dihydro-3H-pyrrole-2-amine as selective subtype modulators of alpha2B or alpha2B and alpha2C adrenoceptors

摘要

A selective modulator of the alpha2B or alpha2B and alpha2C adrenoceptor subtype that is represented by the following formula, for use in a method of treating chronic pain, visceral pain, corneal pain, neuropathic pain, glaucoma, ischemic neuropathies, and other neurodegenerative diseases : where R is selected from the group consisting of H, fluorine, chlorine, and methyl; Ar is an aryl group selected from benzene and pyridine, where said aryl group can be attached to the above moiety at any position and where said aryl group can be unsubstituted or substituted with any functional group selected from C1-7 alkyl, C2-7 alkenyl groups , C2-7 alkynyl, C1-7 alkyloxy, hydroxyl, halogen, nitro, nitrile, trifluoromethyl, amino, thiol and carboxy, and n is an integer from 1 to 5.