2,4,5-trisubstituted imidazoles and their use as antimicrobial agents

摘要

Compound having the structural formula: ** Formula ** or a salt thereof, wherein: R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle or substituted heteroaryl; R4, R5, R6, R7, R8 and R9 are independently selected from hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkylalkyl, alkoxy, alkylthio, acyl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro or cyano; and R10 is H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, acyl, -CH2-aryl or -CH2-heteroaryl; with the proviso that the compounds are different from: 3,3 '- [5- (4-methoxyphenyl) -1H-imidazol-2,4-diyl] bis-1H-indole; 4,5-bis (4-methoxyphenyl) -2- (3-indolyl) imidazole; 3 - ((4,5-diphenyl-1H-imidazol-2-yl) -1-methyl-1H-indole; 3- [4- (4-chlorophenyl) -5-phenyl-1H-imidazol-2-yl] -1-methyl-1H-indole; 3- [4- (4-bromophenyl) -5-phenyl-1H-imidazol-2-yl] -1-methyl-1H-indole; 3- [4- (4-methylphenyl ) -5-phenyl-1H-imidazol-2-yl] -1-methyl-1H-indole; 3- [4- (4-methoxyphenyl) -5-phenyl-1H-imidazol-2-yl] -1-methyl -1H-indole; 3- [4- (4-ethoxyphenyl) -5-phenyl-1H-imidazol-2-yl] -1-methyl-1H-indole; 3- [4,5-bis (4-methoxy diphenyl) -1H-imidazol-2-yl] -1-methyl-1H-indole; 4,4 '- [2- (2-phenyl-1H-indole-3-yl) -1H-imidazol-4,5-diyl] bis [N, N-dimethyl] benzenamine; 4,4 '- [2- (5-chloro-1H-indol-3-yl) -1 H -imidazol-4,5-diyl] bis [N, N-dimethyl] bencenamine; 2 - ((3-indolyl) -4,5-bis [4- (dimethylamino) phenyl] imidazole; 2 - ((3-indolyl) -4,5-bis [4- (diethylamino) phenyl] imidazole; 2- ((2-Phenyl-3-indolyl) -4,5-bis [4- (dimethylamino) phenyl] imidazole; 2- ((2-chloro-3-indolyl) -4,5-bis [4- ( dimethylamino) phenyl] imidazole; 2 - ((2-ethylcarboxylate-3-indolyl) -4,5-bis [4- (dimethylamino) phenyl] imidazole.