Lysine-related derivatives such as HIV aspartyl protease inhibitors

摘要

compound of formula (I) ** Formula ** and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, where n is 3 or 4, where X is H and Y is a linear or branched alkyl group of 1 to 6 carbon atoms substituted with a nitrogen or in which X and Y are the same and are each a linear or branched alkyl group of 1 to 6 carbon atoms substituted with a nitrogen, wherein R1 is selected from the group consisting of: a linear alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, a cycloalkylalkyl group having 3 to 6 carbon atoms in the part cycloalkyl thereof and 1 to 3 carbon atoms in the alkyl part thereof, wherein R2 is selected from the group consisting of: H, a linear alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, a cycloalkyl group of 3 to 6 carbon atoms, and a group d e the formula R2A-CO-, R2A being selected from the group consisting of: a linear or branched alkyl group of 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, a cycloalkylalkyl group having 3 to 6 carbon atoms in the cycloalkyl part thereof and 1 to 3 carbon atoms in the alkyl part thereof, an alkyloxy group of 1 to 6 carbon atoms, tetrahydro-3-furanyloxy, -CH2OH, -CF3, -CH2CF3, - CH2CH2CF3, pyrrolidinyl, piperidinyl, 4-morpholinyl, CH3O2C-, CH3O2CCH2-, Acetyl-OCH2CH2-, HO2CCH2-, 3-hydroxyphenyl, 4- hydroxyphenyl, 4-CH3OC6H4CH2-, CH3NH-, (CH3N2-) -, (CH3CH2CH2) 2N-, HOCH2CH2NH-, CH3OCH2O-, CH3OCH2CH2O-, C6H5CH2O-, 2-pyrrolyl, 2-pyridyl, 3-pyridyl-, 2-pyrazinyl, 2-quinolyl, 3-quinolyl, 4 -quinolyl, 1-isoquinolyl, 3-isoquinolyl, 2-quinoxalinyl, a phenyl group of the formula a picolyl group selected from the group consisting of: a picolyloxy group selected from the group consisting of: **Formula**