METHODS AND KITS FOR DIAGNOSING AND TREATING B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA (B-CLL)

摘要

The present invention relates to methods and kits for detecting severalpolynucleotide sequence found to be indicative of a poor prognosis of B-CLL.All the polynucleotides are transcribed from a region on human chromosome12p21-22. Most of the polynucleotides do not encode larger polypeptides, butmay encode small peptides, they may function as RNAs. Four polynucleotidesencode a novel protein, which in one preferred embodiment can be used as acytokine, preferably as an interleukin. Furthermore the invention relates tomethods and compositions for treating B-CLL in particular poor prognosis B-CLL.