ASSESSMENT OF SLEEP QUALITY AND SLEEP DISORDERED BREATHING BASED ON CARDIOPULMONARY COUPLING

摘要

An assessment of sleep quality and sleep disordered breathing is determinedfrom the cardiopulmonary coupling between two physiological data series. In anembodiment, an R-R interval series is derived from an electrocardiogram (ECG)signal. The normal beats from the R-R interval series are extracted to producea normal-to-normal (NN) interval series. The amplitude variations in the QRScomplex are used to extract to a surrogate respiration signal (i.e., ECG-derived respiration (EDR)) that is associated with the NN interval series. Thetwo series are corrected to remove outliers, and resampled. The cross-spectralpower and coherence of the two resampled signals are calculated over aplurality of coherence windows. For each coherence window, the product of thecoherence and cross-spectral power is used to calculate coherent cross power.Using the appropriate thresholds for the coherent cross power, the proportionof sleep spent in CAP, non-CAP, and wake and/or REM are determined.