PROCESS FOR PRODUCTION OF 3-5-4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL-2-(3-OXO-2-SUBSTITUTED-2,3-DIHYDRO-1,2-BENZISOXAZOL-6-YL)METHOXYPHENYLPROPIONATE ESTER AND INTERMEDIATE FORTHE PROCESS

摘要

A preparation method using as an intermediate6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivativerepresented by general formula(see above formula)wherein R5 is a methyl group that is substituted withone or more optionally substituted phenyl groups, or anoptionally substituted oxygen-containing heterocyclicgroup; X represents a halogen atom, can be used as amethod for safely and easily preparing3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionicacid, whichis useful as an antirheumatic agent, with a high yield.