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USE OF A HYDROPHILIC MATRIX COMPRISING A POLYACRYLIC ACID DERIVATIVE, A CELLULOSE ETHER AND A DISINTEGRANT FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING FEMALE GENITAL DISORDERS
USE OF A HYDROPHILIC MATRIX COMPRISING A POLYACRYLIC ACID DERIVATIVE, A CELLULOSE ETHER AND A DISINTEGRANT FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING FEMALE GENITAL DISORDERS
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机译:包含聚丙烯酸衍生物,纤维素醚和崩解剂的亲水基质在制备治疗女性生殖器疾病的药物中的用途
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摘要
A hydrophilic matrix is disclosed which comprises: a) at least one polyacrylic acid derivative in preferred amounts of 0.5 - 40%, b) at least one cellulose ether in preferred amounts of 30 - 90% and c) at least one disintegrant in preferred amounts of 2 - 50%, with respect to the weight of the matrix. This matrix is used in combination with at least one pharmaceutically acceptable active principle for manufacturing solid bioadhesive controlled release formulations for the treatment of vaginal disorders, such as vulvovaginal candidiasis, bacterial vaginosis or trichomoniasis. The matrix is used in solid formulations in amounts of about 5 - 60%, preferably 20-40%, and the active principle in amounts of about 2- 70 %, preferably 5-50% with respect to the weight of the formulation.
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