TARGETED LIPOSOMES PREPARED BY ETHANOL INJECTION

摘要

The present invention is in the field of drug delivery, and specifically,cationicliposome-based drug delivery. In embodiments, this invention provides methodsof makingligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomesuseful for the delivery ofliposomes to tumors, including brain tumors. In embodiments, the liposomesdelivertemozolomide across the blood-brain barrier for treatment of primary ormetastatic brain tumors.Additional cancers that can be treated with the liposomes includeneuroendocrine tumors,melanoma, prostate, head and neck, ovarian, lung, liver, breast, urogenital,gastric, colorectal,cervical, liposarcoma, rhabdomyosarcoma, choriocarcinoma, pancreatic,retinoblastoma and othertypes of cancer. In another embodiment the liposomes deliver melphalan for thetreatment ofmultiple myeloma, other tumors of the blood or other solid tumors. In stillother embodiments theliposomes can deliver other drugs, including atropine for treatment oforganophosphate poisoning.