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FUNCTION OF CHEMOKINE RECEPTOR CCR8 IN MELANOMA METASTASIS
FUNCTION OF CHEMOKINE RECEPTOR CCR8 IN MELANOMA METASTASIS
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机译:趋化因子受体CCR8在黑色素瘤转移中的作用
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摘要
This invention provides a method of treating a subject who has, or has been treated for, a solid tumor which comprises administering to the subject an antagonist of CCR8 receptors on the surface of tumor cells present in the solid tumor in an amount effective to reduce binding of CCL1 to the CCR8 receptors so as to thereby treat the subject. This invention also provides a method of reducing, or reducing the likelihood of, metastases in a subject who has, or has been treated for, a solid tumor which comprises administering to the subject an antagonist of CCR8 receptors on the surface of tumor cells present in the solid tumor in an amount effective to reduce binding of CCL1 to the CCR8 receptors so as to thereby reduce, or reduce the likelihood of, metastases in the subject.
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