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Methods of treating psoriatic arthritis (PsA) using IL-17 antagonists and PsA response or non- response alleles
Methods of treating psoriatic arthritis (PsA) using IL-17 antagonists and PsA response or non- response alleles
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机译:使用IL-17拮抗剂和PsA反应性或非反应性等位基因治疗银屑病关节炎(PsA)的方法
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摘要
The disclosure is directed to novel predictive methods and personalized therapies for treating psoriatic arthritis (PsA). Specifically, this disclosure relates to methods of treating a patient having PsA by selectively administering an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab, to the PsA patient on the basis of that patient being predisposed to have a favorable response to treatment with the IL-17 antagonist. Also disclosed herein are diagnostic methods useful in predicting the likelihood that a patient having PsA will respond to treatment with an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab.
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