Lactam-bearing limonoids from the twigs and leaves of Amoora tsangii

摘要

#$%^&*AU2014100738A420140731.pdf#####LACTAM-BEARING LIMONOIDS FROM THE TWIGS AND LEAVES OF AMOORA TSANGH ABSTRACT The present invention discloses 12 new lactam-bearing limonoids (amooramides A-L) and provides a method for extracting and isolating such compounds from the twigs and leaves of Amoora tsangii (Meliaceae). Their structures are established primarily on the basis of spectroscopic data. Amooramides A-L are first examples of rings A, B-seco limonoids with unusual lactam side chains including 21 -butenolactams (compounds 1-7) and 23-butenolactams (compounds 8-12) in nature. The present invention also demonstrates that at least one of the 12 amooramides might have anti-inflammation activity since it can significantly inhibit the TNFu-induced NF-KB luciferase activity. DocRef#00126850-CP M006.029.DRF 24 Spec final version