The invention discloses a calling method for endpoint across zones in IP network system. The method implements, simply and conveniently, endpoint addressing and calling across GK zones. The method includes: pre-registering an E.164 alias of every endpoint of each gatekeeper (GK) to its own GK in IP network system, wherein the E.164 alias being consisted of a unique zone prefix in the IP network system and a unique number of said endpoint in its own GK; a calling endpoint directly calling a called endpoint with the E.164 alias of the called endpoint. The method further includes: the calling GK extracting the prefix from E.164 alias of the called endpoint and asking the called GK to translate IP address of the called endpoint; the called GK translating IP address of the called endpoint and returning to the calling GK; the calling GK informing said calling endpoint about IP address of said called endpoint; the calling endpoint sending setup signaling to said called endpoint according to the translate IP address to initiate a call.
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