Cone beam volume CT breast imaging is performed with a gantry frame (206) on which a cone-beam radiation source (210) and a digital area detector (208) are mounted. The patient rests on an ergonomically designed table (202) with a hole or two (204) holes to allow one breast or two breasts to extend through the table such that the gantry frame surrounds that breast. The breast hole is surrounded by a bowl so that the entire breast can be exposed to the cone beam. Spectral and compensation filters are used to improve the characteristics of the beam. A materials library is used to provide x-ray linear attenuation coefficients for various breast tissues and lesions.
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