RECOMBINANT HUMAN FIBROBLAST GROWTH FACTOR-1 AS A NOVEL THERAPEUTIC FOR ISCHEMIC DISEASES AND METHODS THEREOF

摘要

Described is method, comprising the following step: administering to an individual having an ischemic condition or disease a composition comprising a mutant fibroblast growth factor (FGF) protein having a polypeptide sequence that is at least 90% identical to the polypeptide sequence of wild-type human FGF-1 protein, wherein the numbering of the amino acid positions is based on the numbering scheme for the 140 amino acid form of human FGF-1.