PEGYLATED HIGH AFFINITY LEPTINS WITH INCREASED BIOLOGICAL ACTIVITY

摘要

A pegylated leptin agonist comprising a PEG moiety linked to a modified mammalian leptin polypeptide that is identical to wild-type mammalian leptin polypeptide, with the exception that the aspartic acid at the position corresponding to position 23 of the wild- type human leptin (D23) is substituted with a different amino acid residue that is not negatively charged or the threonine at the position corresponding to position 12 of the wild-type human leptin (T12) is substituted with a different amino acid residue that is hydrophobic or a fragment of said modified mammalian leptin polypeptide is provided.