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COMPOSITIONS AND METHODS FOR MODULATING AMPA RECEPTOR-MEDIATED EXCITOTOXICITY
COMPOSITIONS AND METHODS FOR MODULATING AMPA RECEPTOR-MEDIATED EXCITOTOXICITY
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机译:用于调节AMPA受体介导的兴奋性的组合物和方法
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摘要
The present invention provides AMPAR excitotoxicity mediating polypeptides comprising the GluR2 NT1-3-2 (Y142-K172) amino acid sequence (SEQ ID NO:1) or the GAPDH(2-2-1-1) (I221-E250) amino acid sequence (SEQ ID NO:2). Also disclosed are nucleotide sequences encoding the polypeptides, methods of inhibiting GAPDH association with the GluR2 subunit or p53. Methods of inhibiting AMPA receptor mediated excitotoxicity using the polypeptides and nucleic acids are also disclosed.
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机译:本发明提供了包含GluR2 NT1-3-2(Y142-K172)氨基酸序列(SEQ ID NO:1)或GAPDH(2-2-1-1)(I221-E250)氨基酸的AMPAR介导兴奋性多肽。序列(SEQ ID NO:2)。还公开了编码多肽的核苷酸序列,抑制GAPDH与GluR2亚基或p53缔合的方法。还公开了使用多肽和核酸抑制AMPA受体介导的兴奋性毒性的方法。
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