CROSS-LINKED SODIUM HYALURONATE GEL FOR TISSUE FILLER FOR PLASTIC SURGERY AND PREPARATION METHOD THEREOF

摘要

The invention relates to cross-linked sodium hyaluronate gel for tissue filler for plastic surgery and a preparation method thereof. The gel is prepared by enabling sodium hyaluronate alkaline solution, epoxy group containing long-chain alkane and epoxy group containing cross-linking agent to react for 2-5 hours at 35-50°C, then washing, gelling and sterilizing, wherein the molar ratio of the sodium hyaluronate alkaline solution, the epoxy group containing cross-linking agent to the epoxy group containing long-chain alkane is 10:4-1:1-4, and the number of carbon atoms of the epoxy group containing long-chain alkane is 6-18. The gel according to the invention has the advantages that on one hand, enzymolysis resistance can be effectively improved, and the gel is more stable; and on the other hand, the excellent intrinsic biocompatibility of the sodium hyaluronate can be maintained, and injectability is unaffected.