MACROPOROUS ADSORPTION RESIN SPECIAL FOR EXTRACTING CEPHALOSPORIN C AND ITS PREPARATION METHOD

摘要

The invention relates to the macroporous absorbent resin special for extracting cephalosporin C, and process for the preparation is disclosed. Specific surface area of such kinds of adsorbent resins is around 1000-2000m²/g, pore volume is 1.5-2.5ml/g. The preparation method as follows: according to the suspension polymerization to prepare the macroporous copolymer matrix, The mixture of monomer, porogenic agent, initiator of polymerization was put into solution of dissolving some dispersant, then the system was heated to 60-100°C,and maintained for 5-10hours, then the crosslinked macroporous copolymer matrix is obtained. With the existence of inert medium, the above described macroporous copolymer matrix reacted with the Lewis acid as the catalyst at 50-120 °C though the alkylate reaction between the aromatic nucleus. The macroporous absorbent resin special for extracting cephalosporin C descried above possess advantages of high adsorption capacity, good selectivity for target substance, desorption and regeneration easily, and so the high purity of cephalosporin C can be obtained.