CHEMICAL PRECONDITIONING PROCESS FOR CELL MATERIAL TO OBTAIN CHEMICAL EPIGENETIC REPROGRAMMING AND PLURIPOTENCY EXPRESSION

摘要

Chemical preconditioning process for cell material to obtain chemical epigenetic reprogramming and pluripotency expression of stem and multipotent elements of non-embryonic origin, such as pericytes and/or mesenchymal stem cells, and/or adult somatic cells. Said process comprises the step of subjecting a non-expanded tissue derivative comprising said stem and multipotent elements, and/or of subjecting non- embryonic stem cells and/or non-embryonic somatic cells, obtained from a tissue sample or from said derivative, to a mixing with hyaluronic acid esterified with butyric and retinoic acids (HBR).