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AN ISOLATED MONOPHOSPHORYLATED PEPTIDE DERIVED FROM HUMAN ALPHA-ENOLASE USEFUL FOR DIAGNOSIS AND TREATMENT OF PANCREATIC ADENOCARCINOMA, ANTIBODIES DIRECTED AGAINST THE SAID MONOPHOSPHORYLATED PEPTIDE, AND USES THEREOF
AN ISOLATED MONOPHOSPHORYLATED PEPTIDE DERIVED FROM HUMAN ALPHA-ENOLASE USEFUL FOR DIAGNOSIS AND TREATMENT OF PANCREATIC ADENOCARCINOMA, ANTIBODIES DIRECTED AGAINST THE SAID MONOPHOSPHORYLATED PEPTIDE, AND USES THEREOF
An isolated peptide of 12-20 amino acids in length comprising the amino acid sequence SEQ ID NO:1, wherein the serine residue (S) at position 8 of SEQ ID NO:1 is phosphorylated, is provided. Also provided is a human monophosphorylated alpha-enolase isoform wherein the serine residue (S) at position 419 of the human alpha-enolase amino acid sequence (SEQ ID NO:2) is phosphorylated and in which other post-translational modifications may be present. Further provided are antibodies capable of specifically binding the peptide and/or the isoform of the invention. The peptide, the isoform and the antibodies of the invention may be used in the diagnosis and/or amelioration and/or treatment of pancreatic adenocarcinoma.
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机译:提供了分离的长度为12-20个氨基酸的肽,其包含氨基酸序列SEQ ID NO:1,其中SEQ ID NO:1的8位的丝氨酸残基被磷酸化。还提供了人单磷酸化α-烯醇酶同工型,其中人α-烯醇酶氨基酸序列(SEQ ID NO:2)的419位的丝氨酸残基(S)被磷酸化并且其中可以存在其他翻译后修饰。还提供了能够特异性结合本发明的肽和/或同种型的抗体。本发明的肽,同工型和抗体可用于胰腺腺癌的诊断和/或改善和/或治疗。
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