ANTI-HEPARAN SULFATE PEPTIDES THAT BLOCK HERPES SIMPLEX VIRUS INFECTION IN VIVO

摘要

Provided are anti-heparan sulfate peptides and methods that employ those peptides for the prevention or treatment of viral infections, including herpesviral infections such as a-herpesviral, ß-herpesviral, and ?-herpesviral infections, which are exemplified by HSV-1. CMV, and HHV-8 viral infections, respectively. Peptides comprise at least 10 amino acids of the amino acid sequences XRXRXKXXRXRX and/or XXRRRRXRRRXK, wherein X represents any amino acid, which are exemplified by peptides that comprise at least 10 amino acids of the sequence LRSRTKIIRIRH and/or at least 10 amino acids of the sequence MPRRRRIRRRQK. Peptides may be coupled to one or more therapeutic compound(s) to generate peptide-therapeutic compound conjugates, wherein the therapeutic compound may be one or more of a nucleoside analog, an oligosaccharide, and a small molecule.