Chimeric constructs between glioma-homing peptide and cell-penetrating peptides, gHoPe2

摘要

The current invention is based on a unique targeting entity (the homing peptide, which we designate as ''gHo''). gHo is a peptide sequence that has specific properties (glioma targeting), the sequence is characterized within the current invention, by using specific methodology. The novel gHo peptide is further utilized in a delivery system, which, in addition to gHo, consists of the delivery entity (a CPP) and a cargo (the effector molecule, such as chemotherapeutic drug). Therefore, the delivery system itself is also novel, because it combines the transport activity of the CPP and the targeting activity of the gHo.