Method for diagnosing and treating chronic fatigue syndrome

摘要

The present invention relates to a method for diagnosing CFS or a predisposition thereto in vitro which comprises determining the levels of CD25, CD69, NKp46 and CD57 biomarkers in CD56+CD16+ NK cells and comparing with a reference value wherein increased levels of said markers is indicative the subject suffers or is predisposed to suffering CFS. Likewise the invention relates to a kit comprising reagents for assaying the levels of CD25, CD69, NKp46 and CD57 in CD56+CD16+ NK cells and to the use of said kit for the diagnosis of CFS or of a predisposition thereto. In addition, the invention relates to a reagent for inhibiting the expression or activity of at least one biomarker selected from the group consisting of CD69, NKp46 and CD5 or to a reagent for inducing the expression or activity of at least one biomarker selected from CD25, CD57, CD56 and Ki67 for use in the treatment or prevention of CFS in a subject in need thereof. Finally the invention relates to a kit comprising a reagent for inhibiting or inducing a biomarker of the invention and to the use of said kit for the treatment or prevention of CFS.